Research List

No.	Researcher	Title	Abstract	Year
1481	Myint Myint Khin	STUDY ON THE ANTI-ARTHRITIS PROPERTY OF CROTON OBLONGIFOLIUS R. (THETYIN-GYI) LEAVES BY USING PROTEIN DENATURATION METHOD	Leaves of Croton oblongifolius R. (Thetyin-gyi) have been known to use in Myanmar traditional medicine concerning antioxidant, anti-arthritis and antimicrobial activities. Therefore, locally grown C. oblongifolius has been chosen for this study. This research aimed to investigate the anti-arthritis activities of the leaves of C. oblongifolius (Thetyin-gyi). In the present work, anti-arthritis activity and cytotoxicity of the Thetyin-gyi leaves have been determined. The sample was collected from the campus of Inya hostel in Yangon University. The cytotoxicity of watery and ethanol extracts evaluated by brine shrimp cytotoxicity bioassay gave LD50 values as 921 �g/mL and 884.5 �g/mL, respectively. The LD50 value of K2Cr2O7 was 1.5 �g/mL and its cytotoxicity values were between 1 and 10 �g/mL. In vitro anti-arthritic activity of ethanol and watery extracts of leaves of Thetyingyi was investigated by protein denaturation method by using bovine serum albumin and egg albumin. In both methods, the ethanol extract has shown significant activity at the concentrations of 500 �g/mL and the effects were compared with the standard drug diclofenac potassium. So, the ethanol extract of C. oblongifolius have higher anti-arthritic activity than watery extract.	2021
1482	Khin Chaw Win	INVESTIGATION OF ?-GLYCOSIDASE INHIBITON AND ANTIOXIDANT ACTIVITIES OF HYDROCOTYLE ROTUNDIFOLIA ROXB. (SAY-MYIN-KHWA)	This research is focused on the evaluation of ?-glucosidase inhibitory effect from Myanmar Traditional Medicinal Plants Hydrocotyle rotundifolia Roxb. (Say-myin- khwa). The medicinal plant has been reported to possess the antidiabetic potential. According to the preliminary phytochemical tests indicated the presence of alkaloids, ?-amino acids, carbohydrates, flavonoids, glycosides, phenolic compounds, steroids, terpenoids, tannins, reducing sugars, and saponins were present while starch was not detected in this sample. The ?-glucosidase inhibitory effect of watery and ethanol extracts on production of glucose from sucrose was determined by using UV-Visible spectroscopy. The 50 % inhibitory concentrations (IC50) of watery and ethanol extracts on ?-glucosidase activity were found to be 0.73 and 0.61 �g/mL. From this experiment, it was found that ethanol extract showed higher potency than water extract. However, all of these extracts showed lower potency than that of standard drugs Voglibose (IC50 = 0.32 �g/mL in ?-glucosidase inhibitory effect. The antioxidant activity of ethanol and watery crude extracts was investigated by DPPH free radical scavenging assay. The IC50 values of watery and ethanol crude extracts were12.34 �g/mL and 9.33 �g/mL. Since the lower IC50 value, the higher antioxidant activity of the samples occurs. Thus, the ethanol extract showed higher antioxidant activity than that water extract.	2021
1483	Myint Myint Htay	STUDY ON ANTIOXIDANT ACTIVITY, ANTIMICROBIAL ACTIVITY AND ACUTE TOXICITY OF PLUKENETIA VOLUBILIS L. (SACHA INCHI) LEAVES	This research focused on the investigation of phytochemical constituent, mineral content, antioxidant, antimicrobial activities and acute toxicity of sacha inchi leaves. Firstly, the preliminary phytochemical screening was done. The leaves give positive test for alkaloid, flavonoid, glycoside, terpene, steroid, reducing sugar, saponin, tannin and phenolic compound but cyanogenic glycoside was not found. The mineral content was determined by EDXRF spectroscopic technique. The main minerals present in sacha inchi leaves are calcium and potassium. The antioxidant activity of ethanol extract was determined by DPPH assay. The IC50 value of ethanol extract was found to be 179.60 �gmL-1 . Moreover, the antimicrobial activity of ethanol extract was investigated by agar well diffusion method on seven selected microorganisms. Among selected microorganisms, the ethanol extract showed the highest activity on Bacillus pumilus and high activities on Agrobacterium tumefaciens, Bacillus subtilis, Candida albicans, Escherichia coli, Pseudomonas fluorescens and Staphylococcus aureus. In addition, oral acute toxicity test of ethanol extract was studied by Organization of Economic Cooperation and Development (OECD) guideline (425). According to oral acute toxicity test, the tested sacha inchi leaves can be considered relatively safe to the dose level of 5000 mg/kg body weight. No toxicity effects after oral acute exposure of ethanol extract to mice were observed.	2021
1484	Kyawt Kay Khaing	REPARATION AND CHARACTERIZATION OF LIQUID GLUCOSE FROM THE SWEET POTATO STARCH OF POMOEA BATATAS L. (SHWE-KAN-ZUN-U)	The present work deals with isolation and identification of liquid glucose from sweet potato tuber Ipomoea batatas L. (Shwe-ka-zun-u). From the preliminary phytochemical investigation, alkaloids, carbohydrates, ?-amino acids, flavonoids, glycosides, saponins, steroids, tannins, terpenoids, phenolic compounds, starch, organic acids, reducing sugars were found to be present and the cyanogenic glycosides was absent in the tuber of sweet potato. In addition, sweet potato tuber contains the content of water (42.15 %), total solid (57.85 %), nitrogen (0.192 %), ash (1.91 %), fat (0.72 %), starch (48.34 %) and crude fibre (1.97 %). According to ED XRF data analysis, K (65.705 %), Ca (21.918 %), Fe (6.025 %), Rb (3.487 %) and Mn (2.865 %) were observed. The contents of soluble matters using water, ethanol and petroleum were 6.01, 4.14 and 2.23 %, respectively. The yield percent and dextrose equivalent of liquid glucose prepared by enzymatic method and acid hydrolysis method were respectively found to be 11.95 and 11.04 %, 40.37 and 37.30., determined by Fehling's solution method. Similarly, the yield percent of liquid glucose prepared by enzymatic method and acid hydrolysis method were observed as 22.43 and 21.78 %, 75.78 and 73.58, respectively, determined by phenol-sulphuric acid assay. The prepared liquid glucose was characterized by paper chromatographic method. The characteristics of prepared liquid glucose obtained by enzyme hydrolysis and acid hydrolysis were indicated as specific gravity (1.08 and 1.02), refractive index (1.42 and 1.30), viscosity (1.5282 cP and 0.7864 cP), pH (4.4 and 4.8), water content (25.67 % and 31.95 %), total solid (74.33 % and 68.05 %) and sulphated ash (0.048 % and 0.069 %), respectively.	2021
1485	Thin Thin Hlaing	A STUDY ON SOME WATER QUALITY ASSESSMENT OF GAMOEYIEK CREEK WATER SAMPLE NEAR NORTH DAGON TOWNSHIP AND TREATED WITH MORINGA OLEIFERA L. (DANT-DA-LUN) SEEDS	In the present work, the Ngamoeyeik creek water sample was collected from North Dagon Township, Yangon Region. Some physicochemical properties (pH, turbidity, conductivity, chemical oxygen demand, biochemical oxygen demand, total alkalinity, total hardness, total suspended solids and total dissolved solids) of the creek water sample were determined by standard method. Elemental analysis of some trace elements (Cr, Mn, Fe, Cu, Zn, Pb, Cd, Mg, Ca, K, Na and As) of the creek water sample were measured by atomic absorption spectrophotometer (AAS). Bacteriological properties of creek water sample were investigated by AOAC method. The conventional treatment design for creek water was modified by coagulation and flocculation approach. In the lab study, the experiments with two parameters such as doses of M. oleifera seeds powder (1, 2, 3, and 4 g/L) and contact times (1, 2, 3 and 4 h) were conducted to study their effects on the flocculation process. This process showed in significant reducing of turbidity. The optimum conditions for water treatment by using M. oleifera (Dant-da-lun) seeds powder are 2 g/L dose and 1 h of contact time. After treatment the observed values of (pH, total suspended solids, total dissolved solids, Mn, K, Cd, Mg, total coliform and E.coli) are significantly reduced.	2021
1486	Su Lay Yee	STUDY ON WATER QUALITY AND TREATMENT OF TUBE WELL WATER SAMPLES FROM SHWEBO TOWNSHIP, SAGAING REGION	In this study, the water samples were collected from three different locations of Shwebo Township, Sagaing Region. Collected water samples were treated by filtration method by using chipping stones (2?), rice husk char (2?) and sand (2?).Physicochemical parameters such as pH, turbidity, total suspended solid (TSS), total dissolved solid (TDS), total hardness, total alkalinity, chloride, salinity, dissolved oxygen (DO), chemical oxygen demand (COD), biochemical oxygen demand (BOD) of water samples before and after treatment were also investigated by standard method. The mineral elements such as sodium (Na), magnesium (Mg), calcium (Ca) and lead (Pb) contents were also analyzed by atomic absorption spectrometer and arsenic content was determined by arsenator. The obtained results were compared with the WHO standard. The result of mineral determination revealed sodium (Na), Calcium (Ca) and magnesium (Mg) composition in water samples of before and after treatment were found to be within the WHO standard. Furthermore, toxic element lead and arsenic were not detected all samples of before and after treatment. However, water samples showed high total suspended solid (TSS), total dissolved solid (TDS), total alkalinity, chloride, salinity, biochemical oxygen demand (BOD) values indicating poor water quality.	2021
1487	Thin Thin Swe	REMOVAL OF CALCIUM ION FROM WATER BY LUFFA SPONGE L. AEGYPTIACA	Hardness is one of the common water quality problems throughout the world. Luffa sponge can be used as a sorbent material to reduce dissolved calcium and magnesium in hard water. This paper deals with removal of calcium ions from water by using luffa sponge as a sorbent. The luffa sponge sample was collected from Taunggyi Township, Shan State. In order to find out the types of organic constituents present in luffa sponge sample, preliminary phytochemical investigation was carried out by test tube method. Some physicochemical parameters such as ash, moisture and fibre contents of luffa sponge were determined by AOAC methods. The alkali modified luffa sponge sample was prepared by treating with NaOH solution. The feasibility of alkali modified luffa sponge as metal ions adsorbent for Ca2+ ions from aqueous solution was studied in bath experiments at room temperature. Sorption efficiency of alkali modified luffa sponge for calcium ions was investigated by varying pH, initial metal concentration, contact time and sorbent dose. The residual metal ions in aqueous solution will be determined by complexometric titration. Alkali modified luffa sponge and metal loaded alkali modified luffa sponge were characterized by EDXRF and FT IR analyses. It was inferred that alkali modified luffa sponge can be considered as an effective sorbent in the treatment of hard water.	2021
1488	Khin Moh Moh Hlaing	PREPARATION OF SOAP IN THE PRESENCE OF LOCALLY AVAILABLE NATRON	This research work concerns with the preparation of soap from palm oil with locally available natron by hot process method. Locally available natron sample was collected from Aigther village, Wundwin Township, Mandalay Division in winter season. The purified natron was characterized by available modern techniques ED XRF and FT IR analyses. The physicochemical properties of prepared soaps such as texture, color, foam stability (%), foam height (cm), pH, degree of absorption activity (%) and antimicrobial activity etc. were determined. According to the physicochemical properties, all of the prepared soaps were found in the pH range of (10.2-10.8). This pH range was skin friendly pH and was accepted by National Agency for Food and Drug Administration and Control (pH 8-11). Antimicrobial activity of prepared soaps was investigated by agar well diffusion method at Meiktila University. The prepared soaps were found to be active against with Bacillus subtilis, Staphylococcus aureus, Pseudomonas fluorescens, Bacillus pumilus, Candida albicans and Escherichia coli (E.coli). From the preparation�s stand point, the prepared soaps were utilized not only as laundry soap but also as medicated soap.	2021
1489	Thet Naing Soe	COMPARATIVE EVALUATION OF THE PELLETIZED BIOMASS FUEL FROM DIFFERENT SOLID WASTES	This research is aimed to convert the vegetable waste into valuable products as an alternative and sustainable fuel source. This study investigated the potential use of fuel pellets that are produced from the wastes such as radish leaf, rice husk and rice husk char. Some physicochemical properties such as moisture content, ash content, bulk density, and chemical composition (N and S %) of different solid waste samples were carried out using appropriate analytical methods. Furthermore, pellets were produced from radish leaf, rice husk and rice husk char using cassava stem and local algae (Spirogyra sp.) as a binder. The properties of fuel pellets (compact and relax densities, heating value, energy densities, pellet moisture content) were determined as a function of types and sample composition (60 to 80 % w/w) by applied pressure (1.7 MPa). Also comparative studies of the different samples such as radish leaf (R) with rice husk (H) and rice husk char (C) and their toasted samples (TR, TH and TC) were conducted. The results showed that energy densities ranged from 6.183 to 7.613 kJcm-3 , 0.366 to 4.387 kJcm-3 and 0.909 to 1.648 kJcm-3 for the samples R, H and C whereas energy densities ranged from 9.003 to 11.072 kJcm-3 , 0.369 to 4.760 kJcm-3 and 1.116 to 1.876 kJcm-3 for the samples TR, TH and TC, respectively. The heating value was also found in the range of 13.188 - 14.336 kJg-1 , 13.375 kJg-1 and 2.425 - 5.214 kJg-1 for samples R, H and C, and 13.737 - 14.010 kJg-1 , 12.656 - 13.333 kJg-1 and 2.891 - 5.567 kJg-1 for samples TR, TH and TC, respectively. From the findings, the radish leaf waste was found to have good pelletizing and combustion characteristics under the conditions considered because of their high density, high heating value and low pellet moisture content. Properties of the densified products (pellets) appeared to be comparable to US PFI requirements.	2021
1490	Swe Sint	ASSESSING THE APPLICATION OF IRON OXIDE PARTICLES FOR REMEDIATION OF INSECTICIDE CONTAMINATED SOIL	In this study, iron oxide particles were synthesized and used to remediate insecticide contaminated soil. The influence of experimental variables such as reaction time, and particle dosage of iron oxide particles on the soil remediation were studied. The green synthesis of iron oxide particles was prepared by reducing iron (III) chloride solution with tea leaves extract for remediation of the soil. The optimized quantity of iron oxide particles was found to be 0.01 mL/kg of soil contaminated with 0.002 ?g g-1 of cypermethrin insecticide. The physicochemical properties of the soil sample were determined. Iron oxide particles were prepared by green method and characterized by modern techniques such as XRD, FT IR, TG-DTA and FESEM analyses. The degradation of insecticides residue in contaminated soil was studied. The residual insecticide in soil samples extracted from the experimental plot was examined by using UV-Vis spectrophotometer. Insecticide residue did not increase but firstly increased than decreased. The soil urease activity in the treated and contaminated soil was also determined. The stabilization of urease activity in the soils studied was due to iron oxide particles and these had light influence on soil organic matter. These results suggest that only proper amount of iron oxide particles plays a dominating role to control the urease activity of the soils.	2021

Research Publications

Myanmar Academy of Art & Science List of Research