Research List

No.	Researcher	Title	Abstract	Year
21	Theingi WinNaing	APPLICATION OF STARCH AND ITS DERIVATIVE FROM CASSAVA (Maniot escenta Crantz.) AS DISINTEGRANTS IN PHARMACEUTICAL TABLETS FORMULATION	The main aim of the research work focused on the application of the starch and its derivative prepared from cassava (Manihot esculenta Crantz.) and their application in pharmaceutical tablets formulation. The cytotoxicity of aqueous solution of local cassava starch (LCS) and its derivative carboxymethyl cassava starch ( CMCS) were evaluated by brine shrimp cytotoxicity assay. According to the brine shrimp cytotoxicity assay, LCS and CMCS were observed to be free from cytotoxicity (LD50 1000 ppm), up to 1000 g/mL concentration. The morphological characteristics of LCS and CMCS were recorded by using standard plate count method and Gram staining method indicating, the absence of Escherichia coli in both samples. LCS and CMCS were applied as disintegrants with different weights in chlorpheniramine maleate tablets formulation. 2.3 % (w/w) of LCS and 1.2 % (w/w) of CMCS were found to be most suitable for chlorpheniramine maleate tablets formulation determined by their physical properties such as moisture content, thickness, hardness, friability and disintegration times in distilled water as well as 0.1 M HCl solution.	2018
22	Zin Thu Khaing	SOME BIOACTIVITIESOFMA AGISA ROXB. (NA - NWINTAIN- PYAR) RHIOMES	This research work has focused on the elucidation of chemical constituents and some biological activities of the fresh rhizome of C. aeruginosa Roxb. The phytochemical screening of C. aeruginosa Roxb. powder reveals the presence of several compounds. The main phytochemical constituents include alkaloids, carbohydrates, amino acid, flavonoids, phenolic compounds, glycosides, reducing sugars, starch, steroids, terpenoids, and tannins. However, cyanogenic glycoside and saponin were not detected at the assay conditions. In the screening of the antioxidant activity, ethanol extract (IC50= 1.56 g/mL) was found to be more potent than watery extract (IC50 =3.95 g/mL). The total phenol contents (TPC) of ethanol extract (52.31 �8.70 g GAE/mg) was found to be higher than watery extract (16.92 � 0.20 g GAE/mg).The antimicrobial activities of (PE, EtOAc, EtOH and water) extracts from C. aeruginosa Roxb. sample were determined against seven strains of microorganisms (. subtilis, . aureus, P. aeruginosa, . pumilus, C. albicans, E.coli and . tumefaciens) by agar well diffusion method. The highest antimicrobial activity was observed in EtOH extract whereas H2O extract showed minimum activity. Antitumor activity was carried out with EtOAc and EtOH extracts by PCG test. From this experiment, both extracts were found to prevent the tumor formation with the dose of 0.1 and 0.15 mg/disc. The rhizome of C.aeruginosa Roxb.could be applied not only as the local health remedy to the local indigenous but also for the treatment of some bacterial plant pathogen and diseases in agriculture of Myanmar.	2018
23	Myat Myat Thaw	BIOSYNTHESIS OF SILVER NANOPARTICLES BY SIIA ASIS AND ITS UTILIATIONS	In Myanmar, the natural pirulina is produced from the natural lake of Yae Khar lake. The aim of this research was to prepare silver nanoparticles from pirulina platensis and to study its utilizations in biomedical, waste water treatment and some lotions for cosmetic products. Microalgae are microscopic photosynthesis organisms that are found in both marine and fresh environments. pirulina platensis (blue green algae) plays very important role for health food. Silver nanoparticles were prepared by green synthesis of silver nitrate with spirulina at 50C for 3 h and characterized by RD, SEM, AFM, UV visible spectrophotometer and FTIR techniques. Average crystallite size of silver nanoparticles from spirulina were found to be 23.93 nm by using Debye-Scherrer equation. The antimicrobial activity of silver nanoparticles against both gram positive bacteria (acillus subtilis, acillus pumilus, taphylococcus aureus and gram negative bacteria Escherichia coli and Pseudomonas aeruginosa and Candida albicans a fungus strain was done by agar well diffusion method. Among these strains, silver nanoparticles from pirulina platensis on Escherichia coli and Candida albicans showed the highest antimicrobial activity. Silver nanoparticles were applied for the removal of textile dyes in waste water samples. Utilizations of pirulina platensis and silver nanoparticles were performed for the formulation of face cream and body lotion and their sun protection factors (SPF) were observed to be 11.34 and 8.57. It was observed that these products can be used safely for face cream and body lotion because of the pH value and their characteristics of microbiological parameters (total plate count and yeast and mold count) for the cosmetic products compared with commercial products.	2018
24	Khin San Win	STRUCTURE ELUCIDATION OF BIOACTIVE ORGANIC COMPOUND ISOLATED FROM MYANMAR INDIGENOUS MEDICINAL PLANT, itis atioia Roxb.	In this research, itis latifolia Roxb., which is one of the Myanmar indigenous medicinal plants known as Chin taung mwe soke was selected for chemical analysis. Firstly, preliminary phytochemical screening of the tuber of Chin taung mwe soke was carried out, which indicated the presence of alkaloid, flavonoid, glycoside, phenol, polyphenol, sugar, saponin, sterol and terpene. The antimicrobial activity of crude extracts in various solvent systems of the tuber of Chin taung mwe soke was determined by agar well diffusion method on six selected organisms. Furthermore, a pure compound was isolated from the tuber of Chin taung mwe soke as needle shape crystal by Thin Layer and Column Chromatographic methods. The yield percent of this compound was found to be 0.61 % (21 mg) based upon the ethyl acetate crude extract and the melting point was (198-199�C). This pure compound gave positive for sterol test. Moreover, antimicrobial activity of this pure compound was rechecked by using agar well diffusion method. In addition, the molecular formula of pure compound could be determined as applying some spectroscopic methods such as FT IR, 1H NMR, 13C NMR and EI mass spectral data. The complete structure of steriodal derivative compound was elucidated by DF-COSY, HMC, HMBC and DEPT spectroscopic method. Finally, the conformational analysis of an organic compound was carried out by using 1H NMR splitting patterns, coupling constant, NOESY spectral data and model studies. The structure of the isolated compound was elucidated as 10, 11, 15-trimethyl-17-(3-methylnona-2-yl)-2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta [a] phenanthren-3-ol.	2018
25	Khin Khin Wai	STUDY ON THE UPTAKE OF INC(II) AND LEAD(II) BY DRY TARO (PEIN) ASIA SA L.	This researchis concerned with the study on the uptake of Pb(II) and n(II) metal cations by the dry taro (biomass) using batchwise system. The plant sample was collected from thePyay University Campus. The similar shape, size, weight and height of taro plant were selected and washed with tap water, distilled water and dried in air. The dried sample was made to powder by using grinder and sieved with 0.9-1 mm mesh. The determinations of the initial amounts of Pb(II) and n(II) metal cations in taro plant, soil and water from sample site were carried out. It was observed that the initial amounts of n(II) ion in plant, soil and water from sample site was greater than those of Pb(II) ion. In experiment I, 8.5 g of the dried powder sample was packed in a cotton bag and immersed in each of experimental buckets containing 3L of different metal cations with different concentrations separately to determine the uptake ofPb(II) and n(II) metal cations on daily up to 7 days.Moreover in experiment II, the amount of uptake of Pb(II) and n(II) metal cations were examined eight times at the interval of 15 min up to 120 min by adding (8.5 g) each of sample in 150 mL of solutions containing different concentrations of metal cations.The optimum contact time at 45 min for Pb(II) and 60 min for n(II).It could be seen clearly that the uptake capacity for Pb(II) was greater than n(II) in both experiments I and II. The effect of temperature on the uptake of Pb(II) and n(II) by the dry taro (biomass) was studied at the range between 20C and 70C based on 50, 25 and 10 ppm.The optimum temperature was at 40 �C. It was found that, the percent uptake of Pb(II) was higher than n(II) for the concentrations of 50, 25 and 10 ppm. The percent uptake of n(II) was investigated by the acidified biomass of drytaro at the interval of 15 min up to 120 minfor 50 ppm of n(II) solution. It was found that the optimum uptake of n(II) ion was reached at 60 min. The acidified biomass of dry taro was greater in uptake of n(II) ion than the non-acidified biomass of dry taro	2018
26	Phyu Phyu Zaw	STUDY ON SOME DERMATOLOGICAL PROPERTIES AND CHEMICAL CONSTITUENTS OF MYANMA NATURAL COSMETIC eronia imonia (L.) SWINGLE (THEE) BARK	This research is concerned ith the chemical investigation and some dermatological activity of ???. ingle Thee bar. ? antistaphylococcal activities of petether, ethanol and ater crude extracts ere evaluated by investigating the healing potential on ? induced excision type cutaneous ounds. ll extracts too days to heal ound. o significant difference on ound healing effect beteen different doses of mgday as observed. Control group needed days to heal ound. in hitening activity as determined by using a modification of Imoaa Method. In this study, guinea pig as chosen as the experimental animal because its sin histologically and biochemically is similar to the human sin. Petether andethanol extracts, and oic acid control ere topically applied on sun rays induced hyperpigmented sin of guinea pigs for three successive ees. fter ees, petether and ethanol extracts treated portion ere found to be hiter than that of untreated hyperpigmented sin. The hitening effect of petether and ethanol extracts ere found to be similar, hoever, loer than that of oic acid. In chemical investigation, to compounds ere isolated from chloroform extract of ??? Thee bar. These ere Compound I ergapten . yield, mp.C and Compound II marmesin . yield, mp. C.These compounds have been identified by spectroscopic measurement , TIR, MR and C MR.	2018
27	Aung Aung	PREPARATION OF ORGANIC FERTILIERS USING FOR CROP CULTIVATION	rganic fertiliers prepared from organic astes can reduce cost in agricultural sectors and increase soil fertility. This research or concerns ith studies for the preparation of organic fertiliers from rice stra, chicen manure and neem leaves, its application for crop cultivation and studies the effect of fertilier on soil fertility. Rice stra from farmer field, neem leaves from un Chan illage in Taungdingyi Tonship and chicen manure from Pyay Tonship ere collected. The organic fertiliers ere prepared by five different eight ratios g g g, rice stra, chicen manure, neem leaves for organic fertilier , g g g for , g g g for , g g g for , and g g g for . These different fertiliers ere prepared by compost heap method. The physicochemical properties and, content of macronutrients and micronutrients ere determined by EDR, and other modern and conventional methods. It as found that contains ., .P, ., ., .P, ., ., .P, ., ., .P, ., . , .P, ..rom EDR result, the amount of Ca, and i are higher than other elements in five different ratios of organic fertiliers. It as found that, these organic fertiliers contain Ca, Mg, n, Cu, Mn and e by measurement. ccording to these results, it as found that as rich in macronutrients. o as chosen to use for crop cultivation and improving the soil fertility. The rice stra based organic fertiliers should be used as effective fertilier for agricultural section and for reducing the use of chemical fertilier hich can damage the soil fertility.	2018
28	Lin Lin Naing	EFFECT OF CALCINATION TEMPERATURE ON MORPHOLOGICAL, STRUCTURAL AND THERMAL PROPERTIES OF HYDROXYAPATITE DERIVED FROM GOAT BONE	nd family having the formula CaP.Calcination method as used to extract hydroxyapatite from aste goat bone, a useless resource, after deproteiniation. This study focuses the study of p derived from aste goat bone subected to different calcination temperatures oC, oC, oC and oC ith regard to their morphological, structural and thermal properties. Calcination treatment has eliminated the collagen and organic compounds from the p derived from goat bones. EDR spectrum shoed the highest amount of calcium and phosphorus in p samples at all calcination temperatures. nly a single phase of hydroxyapatite as noted in the RD pattern at each calcination temperature and the crystal system as indexed as hexagonal. Crystallinity percent increased from . at oC to . at oC. ith increase in calcination temperature crystallite sie also increased but the increase as not pronounced at higher temperature. The absorption bands of and cm originated by the collagen disappeared after calcination at oC. Thermal analysis revealed that the highest eight loss . accompanied by an exothermic pea as observed for uncalcined hydroxyapatitedue to the loss of organic constituents lie collagen hereas the eight losses ere negligible for the calcined samples.	2018
29	Naing Min Tun	STUD ON PHTOCONSTITUENTS AND BIOACTIVE PROPERTIES OF AVOCADO (rsa Amricana MILL.) SEEDS	The graphene shells ere prepared to apply as the electrosorbent for the electrosorption. irstly, graphene oxide as collected to determine sorption activities of irconium and iron. The solubility dispersion in ater of graphene oxide as studied. nd then, the interaction of irconyl chloride solution ith the graphene oxide as also determined. Moreover, the sorption of iron ith graphene oxide gave the magnetic sorbent. The hollo nanosphere graphene shells ith the thicness of nm ere obtained by the methane pyrolysis on spherical i particles. The electrosorption of a ions aCl aqueous solution as carried out on the nanosphere carbon shells electrodes. The electrosorption of r ions rCl aqueous solution . . mgg on the graphene electrodes as also determined. rom the experimental results the maximum sorption capacity as r . mgg on graphene electrode	2018
30	Khaing Khaing Win	STRUCTURE ELUCIDATION AND SOME BIOACTIVITIES OF PURE ORGANIC COMPOUND FROM THE STEM BARK OF ISS IIS WALL.(AUK-CHINSA)	The stem bar of ?all. uchinsa as selected for the phytochemical screening, the determination of the cytoxicity of the crude extract, the isolation of pure organic compound and the identification of the structure of the isolated compound. The cytotoxic activity of the crude extract as determined in ea cells by , dimethylthiaolyl,diphenyltetraolium bromide MTT assay and it shoed high activity ith IC value of .gm. The pure organic compound KKW-1 as isolated by thin layer and column chromatographic separation techniques. The molecular formula of the isolated compound could be observed according to the RM spectral data. The molecular formula of compound KKW-1 is found as C. In addition, the complete structure of naphthoquinone compound KKW-1 as elucidated by applying D and D MR spectroscopy	2018

Research Publications

Myanmar Academy of Art & Science List of Research