SCREENING OF PHYTOCHEMICALS AND SOME BIOLOGICAL ACTIVITIES OF THE AERIAL PARTS OF BACOPA MONNIERI (L.) WETTST. (BYONE-HMWE)
Abstract
- The aim of the study was to screen some phytochemical constituents of Bacopa monnieri (L.) Byone-hmwe such as total phenolic and total flavonoids contents, and some biological activities such as antioxidant, antimicrobial, and antiproliferative activities. The total phenolic content was determined by Folin-Ciocalteu’s assay and expressed as GAE equivalent. An aluminium chloride colorimetric assay was used to calculate the total flavonoids content, which was then expressed as QE equivalent. The antioxidant activity of ethanol and water extracts of B. monnieri was determined by DPPH assay. These assays found that the ethanol extract (IC50 = 470.15 µg/mL) was more potent than the water extract (IC50 =770.54 µg/mL) in antioxidant activity. The ethyl acetate extract of the plant was found to have high potent antimicrobial activities against all six tested microorganisms, with inhibition zone diameters (21-26 mm) determined by agar well diffusion method those of petether, ethanol and water extracts. The in vitro antiproliferative activity of ethanol extract was more potent against A549 (lung) and Hela (cervical) human cancer cell lines (IC50 = 115.03 µg/mL and IC50 = 129.95 µg/mL) than the water extract determined by MTT assay.
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Year
- 2022
Author
-
Aye Aye Thant
Subject
- Chemistry, Physics, Zoology, Botany and Marine Science, Geology
Publisher
- Myanmar Academy of Arts and Science (MAAS)