Abstract

• The seagrass, Enhalus acoroides, was collected from Pho Htaung Gyaing, Shwe-Thaung-Yan Sub Township on June, 2019 for the isolation of marine derived fungi. The isolation was undertaken by Surface Sterilization Method. Six endophytic fungi were isolated and their antibacterial activities were tested against three test organisms. In the present study, three isolates showed the antibacterial activity against Escherichia coli and among them, fungus FE- 05 showed the highest activity on Escherichia coli. Therefore, fungus FE - 05 was selected for the investigation of the effects of pH and fermentation media on the antibacterial activity against Escherichia coli. In this study, the maximum antibacterial activity of secondary metabolite produced from fungus FE- 05 was observed in Potato Yeast Extract Medium under pH 6.5. According to identification result, the selected fungus FE - 05 was identified as Cladosporium sp.