Abstract

• The present study was conducted to investigate the bioactive metabolites from endophytic fungus isolated from Gynura procumbens (Lour.) Merr. leaves, which is locally known as Pyar-mee-ywet. A total of 17 strains were isolated from the leaf of selected medicinal plant. Among them, selection of the target fungus for further investigation was done based on chemical screening (spot pattern on TLC). From the culture broth of the selected fungus, perylenequinone derivatives, stemphyltoxin II (1), alterperylenol (2) and stemphyltoxin III (3), together with common fungal metabolites, 4-hydroxy-benzaldehyde (4), adenosine (5) and uridine (6) were isolated using various chromatographic methods. The structure elucidation of the isolated compounds was performed based on NMR and mass data.