Abstract

• The aim of present study is to screen some bioactivities and to isolate mangostin from the pericarp of Garcinia mangostana L.(Mangosteen). Firstly, the phytochemical constituents were investigated by the reported chemical methods. The qualitative elemental analysis was done by EDXRF technique. The extractable matter contents were determined by extracting sample with polar solvents such as ethanol and water. In the study of the antioxidant activity, ethanol and watery extracts were screened by DPPH radical scavenging assay. The ethanol extract (IC50 = 8.15 µg/mL) was found to be more potent than watery extract (IC50 = 12.3 µg/mL) in antioxidant activity. In addition, the antitumor activity of ethanol and watery extracts was investigated by Potato Crown Gall (PCG) test and both extracts exhibited antitumor activity with the doses of 0.15, 0.1 and 0.05 g/disc. Furthermore, the mangostin (0.09 %, 180-181°C) was isolated from the ethanol extract by column chromatographic separation technique. The isolated compound was identified by spectroscopic techniques compared with authentic mangostin.