Abstract

• Three different soil samples were collected from Minhla Area, Magway Region during July 2018. A total of 15 fungal strains were isolated by serial dilution method from these soil samples. These strains were cultured on Blaskeslee’s Malt Extract Agar (BMEA Medium), Czapek-Dox Agar (CZA Medium), Malt Extract Agar (MEA Medium), Dichloran Rose Bengal-Chloramphenicol Agar (DRBC Medium), Glucose Ammonium Nitrate Agar (GAN Medium) and Potato Dextrose Agar (PDA Medium). Pure colonies were preserved on slant culture containing PDA Medium. Among all of media, BMEA medium and PDA medium are better for isolation of soil fungi than other media. In the colony morphology, the isolated fungi were small, medium and large in size. The margin of isolated fungi were entire, undulate, and the elevation of isolated fungi were raised, convex, flat. In the form, isolated fungi were circular, irregular and filamentous. Moreover, physicochemical properties of soil from different locations of Minhla Area were analyzed. Furthermore, all fungal strains were tested by eight test organisms for the antimicrobial activity. Especially, the isolated fungi YY- 6, 11, 14 and 15 showed the antimicrobial activity against all test organisms. Among them, YY-6 showed the highest antimicrobial activity (32.82 mm and 31.47 mm) on Candida albicans and Escherichia coli, respectively.