Abstract

• Soil sample collection was carried out on the 28th June, 2018 from the Shin Ma Taung and on the 29th June, 2018 from Pone Taung Pone Nyar Areas. Totally, 23 fungi (13 from Shin Ma Taung and 10 from Pone Taung Pone Nyar) were isolated from 15 different soil samples by Chemical Treatment Dilution Method. The specimens were cultured on Low Carbon Agar (LCA) and Glucose Soluble starch Yeast extract (GSY) plates and incubated at room temperature. Fungus MMH-11 possessed the highest antibacterial activity among the fungi of Shin Ma Taung Area. Among the fungi of Pone Taung Pone Nyar Area, fungus MMH-23 possessed the highest antibacterial activity. Fungus MMH-23 was selected for further investigations because it exhibited more high antibacterial activity on Methicillin Resistance Staphylococcus aureus (MRSA). The growth phase of the selected fungus MMH-23 was between 36 h and 72 h. Age of inoculum (42 h seed culture), size of inoculum (20 %) and initial fermentation pH 6.0 were suitable for the production of bioactive compound against MRSA.