Abstract

• In this present study, seven different soil samples were collected in the Tha-Beik-Kyin area of Mandalay region for the isolation of soil microorganisms. After that soil fungi were isolated from different soil samples at Biological Resource and Biotechnology Development Center (BRBDC) of Botany Department in Pathein University. Eleven fungi were isolated from these seven different soil samples by using physical treatment dilution method on low carbon medium. Then, the isolated fungi were photographed and the studies were conducted on their respective morphological characters. Following that, antimicrobial activities of the fungi were tested by the paper disc diffusion assay method. In the study of antimicrobial activities, 8 different test organisms were utilized. According to the results, three isolated strains (MAI 01, MAI 06, and MAI 07) showed activity against the test organisms. Among them, strain MAI-07 showed the highest antibacterial activity against Bacillus subtilis (25.70 mm). In the fermentation studies, 84 hr age and 15% size of inoculums were optimized for the fermentation. Carbon sources (glucose, glycerol) and nitrogen sources (yeast extract, polypeptone) showed the best activities on the fermentation.