STUDY ON CONSTITUENTS IN MYANMAR TRADITIONAL MEDICINAL PLANT oloptelea integriolia (ROXB.) PLANCH
Abstract
- (Roxb.) Planch (Ulmaceae) is a tree widely distributed on the Myanmar, India, Indochina and Asia, and it is locally called in Myanmar as “Pyauk-seik”. The various extracts of stem bark of were analyzed by Thin Layer and Column Chromatography method. The stem barks of were collected from Chaik Village, Pakokku Township, Magway Region, Myanmar. They were washed, driedin shade, weighed and cut into small pieces and extracted in methanol. The fractionation of crude extract, followed by the addition of distilled water, n-hexane , ethyl acetate and n-butanol to an aqueous portion of each solvent, to obtain the dried masses of each four layers. Three pure compounds such as new 2-(2-hydroxyethylamino)-1,4 -naphthoquinone (1),(-)-syringaresinol (2), and(+) (4S)-4-hydroxy--tetralone (3) are isolated from ethyl acetate portion of this plant. The structures of these compounds were elucidated by analysis of NMR spectroscopic and mass spectrometric data. Although compound (1) is synthetically known, to the best of our knowledge, there is no previous report of its natural occurrence. The compounds (2 and 3) are described for first time from species. Moreover, the antioxidant activity of compound3was evaluated by measuring the half inhibition concentration (IC50) using chemiluminescent method. This isolated compound was found to exhibit significant antioxidant property which is comparable to standard ascorbic acid, at a specific concentration.
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Year
- 2018
Author
-
Arnt Win
Subject
- Chemistry
Publisher
- Myanmar Academy of Arts and Science (MAAS)